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标题：Adiponectin: Role in physiology and pathophysiology
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作者：ThiMong Diep Nguyen
期刊名称：INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
印刷版ISSN：2008-7802
出版年度：2020
卷号：11
期号：1
页码：136-144
DOI：10.4103/ijpvm.IJPVM_193_20
出版社：ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptors, AdipoR1 and AdipoR2. In addition, adiponectin is one of the hormones with the highest plasma concentrations. Weight loss or caloric restriction leads to increasing adiponectin levels, and this increase is associated with increased insulin sensitivity. Therefore, the adiponectin pathway can play a crucial role in the development of drugs to treat type 2 diabetes mellitus and other obesity-related diseases affected by insulin resistance like cancers or cardiovascular diseases. Adiponectin appears to increase insulin sensitivity by improving glucose and lipid metabolisms. The objective of this review is to analyze current knowledge concerning adiponectin and, in particular, its role in physiology and pathophysiology. Copyright: © 2020 International Journal of Preventive Medicine.
关键词：AdipoR;Adipokines;adiponectin;obesity;type 2 diabetes mellitus