首页    期刊浏览 2024年11月27日 星期三
登录注册

文章基本信息

  • 标题:Multiple Micronutrients, Including Zinc, Selenium and Iron, are Positively Associated with Anemia in New Zealand Aged Care Residents
  • 本地全文:下载
  • 作者:Sue O. MacDonell ; Jody C. Miller ; Michelle J. Harper
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2021
  • 卷号:13
  • 期号:4
  • 页码:1072
  • DOI:10.3390/nu13041072
  • 出版社:MDPI Publishing
  • 摘要:Anemia is a significant comorbidity for older adults not fully attributable to iron deficiency. Low-grade inflammation and other micronutrient deficiencies also contribute. This cross-sectional study examined the relationships between nutrient and non-nutrient factors with hemoglobin and anemia in 285 residents (>65 years) of 16 New Zealand aged-care facilities. Blood samples were analyzed for hemoglobin, ferritin, sTfR, hepcidin, zinc, selenium, and interleukin-6 (IL-6), (with ferritin, sTfR, zinc and selenium adjusted for inflammation). Linear regression models examined the relationships between micronutrient biomarkers (iron, zinc, selenium, vitamin B-12 and D), age, sex, and health factors with hemoglobin. Thirty-two percent of participants exhibited anemia, although <2% had either depleted iron stores or iron deficiency. Plasma zinc and selenium deficiencies were present in 72% and 38% of participants, respectively. Plasma zinc and total body iron (TBI) were positively associated (p < 0.05) with hemoglobin, while gastric acid suppressing medications, hepcidin, and interleukin-6 were inversely associated. These relationships were maintained after the application of anemia cut-offs. These findings emphasize the importance of considering multiple micronutrient deficiencies as risk factors for anemia.
  • 关键词:anemia; inflammation; nursing home; anti-secretory medications; proton pump inhibitors; interleukin-6; soluble transferrin receptor; total body iron anemia ; inflammation ; nursing home ; anti-secretory medications ; proton pump inhibitors ; interleukin-6 ; soluble transferrin receptor ; total body iron
国家哲学社会科学文献中心版权所有