首页    期刊浏览 2025年07月08日 星期二
登录注册

文章基本信息

  • 标题:Environmentally induced ribosomal DNA (rDNA) instability in human cells and populations exposed to hexavalent chromium [Cr (VI)]
  • 本地全文:下载
  • 作者:Jianlin Lou ; Shoukai Yu ; Lingfang Feng
  • 期刊名称:Environment International
  • 印刷版ISSN:0160-4120
  • 电子版ISSN:1873-6750
  • 出版年度:2021
  • 卷号:153
  • 页码:106525
  • DOI:10.1016/j.envint.2021.106525
  • 出版社:Pergamon
  • 摘要:Hexavalent Chromium [Cr (VI)] is an established toxicant, carcinogen, and a significant source of public health concern. The multicopy ribosomal DNA (rDNA) array is mechanistically linked to aging and cancer, is the most evolutionarily conserved segment of the human genome, and gives origin to nucleolus, a nuclear organelle where ribosomes are assembled. Here we show that exposure to Cr (VI) induces instability in the rDNA, triggering cycles of rapid, specific, and transient amplification and contraction of the array in human cells. The dynamic of environmentally responsive rDNA copy number (CN) amplification and contraction occurs at doses to which millions of individuals are regularly exposed. Finally, analyses of human populations occupationally exposed to Cr (VI) indicate that environmental exposure history and drinking habits but not age shape extensive naturally occurring rDNA copy number variation. Our observations identify a novel pathway of response to hexavalent chromium exposure and raise the prospect that a suite of environmental determinants of rDNA copy number remain to be discovered.
  • 关键词:Chromium ; Ribosome ; rDNA ; Nucleolus ; Copy number
国家哲学社会科学文献中心版权所有