标题：Metabolomics reveals sex-specific metabolic shifts and predicts the duration from positive to negative in non-severe COVID-19 patients during recovery process
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2021
卷号：19
页码：1863-1873
DOI：10.1016/j.csbj.2021.03.039
出版社：Computational and Structural Biotechnology Journal
摘要：Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC–MS-based untargeted metabolomics to analyze plasma metabolic characteristics in men and women with non-severe COVID-19 at both acute period and 30 days after discharge. The results demonstrate that metabolic alterations in plasma of COVID-19 patients during the recovery and rehabilitation process were presented in a sex specific manner. Overall, the levels of most metabolites were increased in COVID-19 patients after the cure relative to acute period. The major plasma metabolic changes were identified including fatty acids in men and glycerophosphocholines and carbohydrates in women. In addition, we found that women had shorter length of hospitalization than men and metabolic characteristics may contribute to predict the duration from positive to negative in non-severe COVID-19 patients. Collectively, this study shed light on sex-specific metabolic shifts in non-severe COVID-19 patients during the recovery process, suggesting a sex bias in prognostic and therapeutic evaluations based on metabolic profiling.
关键词：COVID-19 ; SARS-CoV ; Metabolism ; Sex difference ; Fatty acid ; ALT Alanine aminotransferase ; AP Acute period (AP) ; APTT Activated partial thromboplastin time ; BCAAs Branched‐chain amino acids ; BP Blood platelet ; CA Carbamide ; COVID-19 Novel coronavirus disease 2019 ; CRP C-reactive protein ; DAA Dehydroascorbic acid ; DD D-dimer ; DP Diastolic pressure ; FIB Fibrinogen ; FP Follow-up period ; GPCs Glycerophosphocholines ; HGB Hemoglobin ; LY Lymphocyte ; NG Neutrophilic granulocyte ; NK Natural killer ; PCT Procalcitonin ; PLS-DA Partial least squares-discriminant analysis ; PLSR Partial least squares regression ; PT Prothrombin time ; PTC Phosphatidylcholine ; RDW Red cell distribution width ; RR Respiratory rate ; S1P Sphingosine-1-phosphate ; TBL Total B lymphocyte ; TTL Total T lymphocyte ; WBC White blood cell
