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  • 标题:TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells
  • 本地全文:下载
  • 作者:Matthias Vanderkerken ; Bastiaan Maes ; Lana Vandersarren
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2020
  • 卷号:117
  • 期号:49
  • 页码:31331-31342
  • DOI:10.1073/pnas.2009847117
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Antigen-presenting conventional dendritic cells (cDCs) are broadly divided into type 1 and type 2 subsets that further adapt their phenotype and function to perform specialized tasks in the immune system. The precise signals controlling tissue-specific adaptation and differentiation of cDCs are currently poorly understood. We found that mice deficient in the Ste20 kinase Thousand and One Kinase 3 (TAOK3) lacked terminally differentiated ESAM CD4 cDC2s in the spleen and failed to prime CD4 T cells in response to allogeneic red-blood-cell transfusion. These NOTCH2- and ADAM10-dependent cDC2s were absent selectively in the spleen, but not in the intestine of Taok3 −/− and CD11c-cre Taok3 fl/fl mice. The loss of splenic ESAM cDC2s was cell-intrinsic and could be rescued by conditional overexpression of the constitutively active NOTCH intracellular domain in CD11c-expressing cells. Therefore, TAOK3 controls the terminal differentiation of NOTCH2-dependent splenic cDC2s.
  • 关键词:thousand and one kinase ; dendritic cell ; Notch signaling
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