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  • 标题:Dual self-regulated delivery of insulin and glucagon by a hybrid patch
  • 本地全文:下载
  • 作者:Zejun Wang ; Jinqiang Wang ; Hongjun Li
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2020
  • 卷号:117
  • 期号:47
  • 页码:29512-29517
  • DOI:10.1073/pnas.2011099117
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Reduced β-cell function and insulin deficiency are hallmarks of diabetes mellitus, which is often accompanied by the malfunction of glucagon-secreting α-cells. While insulin therapy has been developed to treat insulin deficiency, the on-demand supplementation of glucagon for acute hypoglycemia treatment remains inadequate. Here, we describe a transdermal patch that mimics the inherent counterregulatory effects of β-cells and α-cells for blood glucose management by dynamically releasing insulin or glucagon. The two modules share a copolymerized matrix but comprise different ratios of the key monomers to be “dually responsive” to both hyper- and hypoglycemic conditions. In a type 1 diabetic mouse model, the hybrid patch effectively controls hyperglycemia while minimizing the occurrence of hypoglycemia in the setting of insulin therapy with simulated delayed meal or insulin overdose.
  • 关键词:glucose-responsive ; insulin delivery ; glucagon delivery ; microneedle patch ; hypoglycemia
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