期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：24
页码：13329-13338
DOI：10.1073/pnas.1914345117
出版社：The National Academy of Sciences of the United States of America
摘要：Two-dimensional (2D) molybdenum disulfide (MoS 2 ) nanomaterials are an emerging class of biomaterials that are photoresponsive at near-infrared wavelengths (NIR). Here, we demonstrate the ability of 2D MoS 2 to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS 2 and NIR stimulation of MoS 2 with human stem cells is investigated using whole-transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence of MoS 2 and NIR stimulation of MoS 2 on integrins, cellular migration, and wound healing. The combination of MoS 2 and NIR light may provide new approaches to regulate and direct these cellular functions for the purposes of regenerative medicine as well as cancer therapy.
