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  • 标题:Reply to Pan et al.: Whole blood metabolome analysis combined with comprehensive frailty assessment
  • 本地全文:下载
  • 作者:Masahiro Kameda ; Takayuki Teruya ; Mitsuhiro Yanagida
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2021
  • 卷号:118
  • 期号:1
  • 页码:1
  • DOI:10.1073/pnas.2016640118
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:As frailty patients are vulnerable to stressors, due to declined physiological capacity of organs during aging, comprehensive frailty assessment efficiently predicts health risk of elderlies (1). First, Pan et al. raise concerns about the definition of frailty (2). Currently, there are three major approaches to defining “frailty”: 1) the physical frailty model by Fried Cardiovascular Health Study Index (CHS), 2) the deficit accumulation model covering multimorbidity by Rockwood Frailty Index, and 3) the Edmonton Frailty Scale (EFS) or Tilburg Frailty Indicator, as mixed physical and psychosocial models (3). Thus, EFS is recognized as a valid and reliable measurement tool for the identification of frailty (4) and widely.
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