期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2021
卷号：118
期号：1
页码：1
DOI：10.1073/pnas.2016187118
出版社：The National Academy of Sciences of the United States of America
摘要：We recently read, with great interest, the article by Kameda et al. (1). They conducted untargeted metabolomics analysis of whole blood samples of 19 older adults; identified 22 markers for frailty, cognition, and hypomobility; and find the following: 1) Metabolite profiles can efficiently distinguish frailty from nonfrailty; 2) antioxidant ergothioneine is neuroprotective; and 3) oxidative stress may be key to frailty and age-related illnesses. While this study makes a significant contribution to the current understanding of metabolomics and frailty, we have a few concerns. First, in this study, frailty was diagnosed … [↵][1]1To whom correspondence may be addressed.
