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  • 标题:Natural Molecules in the Management of Polycystic Ovary Syndrome (PCOS): An Analytical Review
  • 本地全文:下载
  • 作者:Matteo Iervolino ; Elisa Lepore ; Gianpiero Forte
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2021
  • 卷号:13
  • 期号:5
  • 页码:1677
  • DOI:10.3390/nu13051677
  • 出版社:MDPI Publishing
  • 摘要:Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by chronic ovulation dysfunction and hyperandrogenism. It is considered the most common endocrinological disorder, affecting up to 25% of women of reproductive age, and associated with long-term metabolic abnormalities predisposing to cardiovascular risk, such as insulin resistance (IR), dyslipidemia, endothelial dysfunction, and systemic inflammation. PCOS is also characterized by elevated serum levels of luteinizing hormone (LH), causing a condition of hyperandrogenism and a consequent altered ratio between LH and the follicle stimulating hormone (FSH). Over the years, several different approaches have been proposed to alleviate PCOS symptoms. Supplementation with natural molecules such as inositols, resveratrol, flavonoids and flavones, vitamin C, vitamin E and vitamin D, and omega-3 fatty acids may contribute to overcoming PCOS pathological features, including the presence of immature oocyte, IR, hyperandrogenism, oxidative stress and inflammation. This review provides a comprehensive overview of the current knowledge about the efficacy of natural molecule supplementation in the management of PCOS.
  • 关键词:polycystic ovary syndrome; myo-inositol; D-chiro-inositol; resveratrol; vitamin C; vitamin E; vitamin D; omega-3 fatty acids polycystic ovary syndrome ; myo-inositol ; D-chiro-inositol ; resveratrol ; vitamin C ; vitamin E ; vitamin D ; omega-3 fatty acids
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