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  • 标题:N-Acyltriazinedione; a Novel Acylating Reagent Synthesized from a Triazinone-Type Condensing Reagent
  • 本地全文:下载
  • 作者:Kohei Yamada ; Jeongsu Lee ; Mika Kota
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2021
  • 卷号:69
  • 期号:5
  • 页码:498-502
  • DOI:10.1248/cpb.c20-00952
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:In this paper, we report the synthesis of N -acyltriazinedione via the unexpected O – N acyl rearrangement of acyloxytriazinone and its utility as an acylating reagent. N -Acyltriazinedione can be isolated by silica gel column chromatography and reacts with amines in the absence of any base to give the corresponding amides in good yields.
  • 关键词:acylating reagent;triazinedione;O–N acyl rearrangement
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