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  • 标题:Advances in Electrochemical and Acoustic Aptamer-Based Biosensors and Immunosensors in Diagnostics of Leukemia
  • 本地全文:下载
  • 作者:Tibor Hianik
  • 期刊名称:Biosensors
  • 电子版ISSN:2079-6374
  • 出版年度:2021
  • 卷号:11
  • 期号:6
  • 页码:177
  • DOI:10.3390/bios11060177
  • 出版社:MDPI Publishing
  • 摘要:Early diagnostics of leukemia is crucial for successful therapy of this disease. Therefore, development of rapid, sensitive, and easy-to-use methods for detection of this disease is of increased interest. Biosensor technology is challenged for this purpose. This review includes a brief description of the methods used in current clinical diagnostics of leukemia and provides recent achievements in sensor technology based on immuno- and DNA aptamer-based electrochemical and acoustic biosensors. The comparative analysis of immuno- and aptamer-based sensors shows a significant advantage of DNA aptasensors over immunosensors in the detection of cancer cells. The acoustic technique is of comparable sensitivity with those based on electrochemical methods; moreover, it is label-free and provides straightforward evaluation of the signal. Several examples of sensor development are provided and discussed.
  • 关键词:leukemia; biosensor; nucleic acid aptamers; immunosensors; electrochemical detection; acoustic sensors leukemia ; biosensor ; nucleic acid aptamers ; immunosensors ; electrochemical detection ; acoustic sensors
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