期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2021
卷号：118
期号：24
页码：1
DOI：10.1073/pnas.2107030118
出版社：The National Academy of Sciences of the United States of America
摘要：Most cells spend the vast majority of their energy making ribosomes, the machines that translate messenger RNA into protein. The ribosome is a tremendously elaborate machine comprising over 80 individual ribosomal proteins and four ribosomal RNAs. The biogenesis of these machines requires an additional 200 different factors. This amazing assembly feat is accomplished 30 times per second in a growing yeast cell (1) and 125 times per second in a growing human tissue culture cell (2). Given the complexity, frequency, and significance of the task, it is no wonder that human syndromes exist in which ribosome biogenesis is disrupted by a genetic mutation, such as the one described in PNAS (3).
