标题：Comparison of the Prevalence of Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) among Staphylococcus aureus Isolates in a Burn Unit with Non-Burning Units
出版社：THE SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: Staphylococcus aureus ( S. aureus ) is one of the most important pathogens in burn infections colonized in the nose and increase the risk of infections. Methods: Overall, 85 S. aureus isolates were isolated from clinical and nasal hospitalized patients and health care workers (HCWs) in a burn unit and non-burn units in Isfahan from June 2016 and September 2016. Genes encoding penicillin-binding protein 2a (mec A) and adhesive surface proteins, including fibronectin-binding proteins ( fnbA , fnbB ), fibrinogen binding protein ( fib ), laminin-binding protein( eno ), collagen binding protein ( cna ), elastin binding protein (ebps), intracellular adhesion operon ( ica A and ica D) were detected using PCR method. Results: The rate of methicillin-resistant S. aureus (MRSA) among burn and non-burn isolates were 62% (18/29) and 25% (14/56), respectively. The most prevalent MSCRAMMs genes in burn units were eno (86%) and fib (66%). The most common gene pattern in burn center was ica A fib eno. The frequency of ica D, fib and ebp S was higher in clinical samples than nasal samples. No relation was found between the MSCRAMMs genes in the burn unit and non-burn units. Conclusion: The high prevalence of MRSA in burn center can be a new challenge for clinicians. The higher frequency of ica D, fib and ebp S in clinical isolates than nasal isolates may reflect the important role of these genes in colonization and pathogenesis of S. aureus .
