期刊名称：Journal of Radiation Research and Applied Sciences
印刷版ISSN：1687-8507
出版年度：2021
卷号：14
期号：1
页码：44-50
DOI：10.1080/16878507.2020.1855911
出版社：Elsevier B.V.
摘要：Whether calsyntenin 1 (CLSTN1) and serine hydroxymethyltransferase 2 (SHMT2) are sensitive to low-dose ionizing radiation (LDIR) has not yet been defined. Therefore, here, we aimed to investigate changes in gene expression in hepatic cell lines and in blood cells and serum from irradiated mice. Levels of SHMT2 and CLSTN1 were decreased in cancer (HepG2) and normal (HH) hepatocytes exposed to various radiation doses. The mRNA expression of SHMT2 and CLSTN1 was altered in response to 0.5 or 4 Gy of radiation at 24 h post irradiation in vivo . However, plasma SHMT2 protein levels did not change at either radiation dose relative to those in the non-irradiated group. Plasma CLSTN1 protein levels notably decreased in response to 4 Gy of radiation but were not altered in response to 0.5 Gy of radiation. Thus, our findings suggest that the mRNA and protein levels of CLSTN1 might be useful biomarkers for radiation exposure. Further studies are needed to characterize the molecular regulation and functional roles of SHMT2 and CLSTN1 in response to radiation.
