期刊名称：Journal of Radiation Research and Applied Sciences
印刷版ISSN：1687-8507
出版年度：2021
卷号：14
期号：1
页码：125-132
DOI：10.1080/16878507.2021.1881400
出版社：Elsevier B.V.
摘要：The focus of the staged work was radiolabelled 5,7,3ʹ, 4ʹ tetra-hydroxy flavone (Luteolin), isolated from Plantago lanceolata L., (F. Plantaginaceae), with 99m technetium ( 99m Tc) to produce a natural tracer 99m Tc-Luteolin ( 99m Tc-Lut), and to evaluate the biological distribution in silico and in vivo . Labeling was carried out by reduction reaction using SnCl 2 as reducing agent giving a maximum radiochemical yield (RCY) up to 97% at 40°C, pH4, for 30 min., with concentration of 99m Tc and Luteolin of 150 μL. The tracer ( 99m Tc-Lut) showed 12 h., in vitro stability. In silico ADMET screening of 99m Tc-Lut indicated its high bioavailability in all body organs. The bio-distribution profile indicating the highly uptake of the tracer 99m Tc-Lut, in tumor mice target/non-target ratio (T/NT) up to two-fold compared to normal mice, whereas the clearance from mice was observed via both renal and feces pathway. 99m Tc-Lut, could be valued as a probable natural radiopharmaceutical tracer for tumor appearance.
