期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2021
卷号：62
期号：4
页码：507-515
DOI：10.3341/jkos.2021.62.4.507
出版社：The Korean Ophthalmological Society
摘要：Purpose To explore whether panretinal photocoagulation (PRP) improved retinal blood circulation in patients with diabetic retinopathy of various levels of severity based on changes in the retinal circulation time as measured by video fluorescein fundus angiography. Methods We recruited patients with severe diabetic retinopathy indicated for PRP; we performed video fluorescein fundus angiography before and after PRP. We measured changes in the arterial circulation time (ACT), arteriovenous passage time (APT), and venous filling time (VFT) in patients with diabetic retinopathy of varying severity, and compared the findings. We recorded HbA1c levels and hypertension status. Results We enrolled 33 patients, 17 with severe nonproliferative diabetic retinopathy (NPDR) and 16 with early proliferative diabetic retinopathy (PDR). After PRP, neither the ACT nor the APT changed significantly in patients with severe NPDR ( p = 0.927, p = 0.138) or early PDR ( p = 0.137, p = 0.268). After PRP, the VFT was significantly reduced in patients with both severe NPDR ( p = 0.000) and early PDR ( p = 0.022). The VFT reductions were similar in both groups ( p = 0.217). Conclusions In patients with severe NPDR and early PDR, improvements in retinal blood circulation after PRP are reflected by reductions in the VFT evident on video fluorescein fundus angiography. We speculate that the improvements are similar in patients with severe NPDR and early PDR.
其他关键词：Arteriovenous passage time, Diabetic retinopathy, Fluorescein angiography, Panretinal photocoagulation, Venous filling time
