期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2021
卷号：62
期号：5
页码：595-604
DOI：10.3341/jkos.2021.62.5.595
出版社：The Korean Ophthalmological Society
摘要：Purpose To investigate the changes in retinal and choroidal vessels according to changes in thyroid stimulating immunoglobulin (TSI) in patients with thyroid eye disease (TED). Methods A total of 41 patients (82 eyes) with TED were enrolled. The subjects were divided into two groups: an experimental group with clinically significant TSI sample-to-reference ratio (%) abnormalities (> 140) and a control group. Within the experimental group, the median value of 451 was used to further classify patients into groups A and B. Using optical coherence tomography/angiography, the sizes of the superficial fovea avascular zone (sFAZ) and deep fovea avascular zone, the diameter of the macular center 1 mm fovea, 3 mm parafovea superficial capillary plexus density (sCPD), deep capillary plexus density, choroidal thickness, and choroidal vascularity index were measured. Results In the experimental group, the change in the TSI value and the change in the 3 mm parafovea sCPD showed a significant positive correlation ( p = 0.040) with a correlation coefficient of 0.307. Among group B patients of the experimental group, the changes in the TSI value and sFAZ showed a strong negative correlation (-0.417), but it was not statistically significant ( p = 0.053). Conclusions In TED patients with clinically significant TSI levels (> 140), blood vessel density in the superficial layer of the 3 mm parafovea significantly increased with TSI. Especially in the high TSI (≥ 451) group, superficial retinal vessel density.
