摘要：Background. Hypothyroidism is caused by an increase in the concentration of thyroid hormone caused by the smaller production or exogenous administration of the hormone. Physical training improves the endothelial function in hypothyroidism,which indicates the disordered physiology of several endothelium-derived vasoactive factors,e.g.,nitric oxide. Physical exercise affects the obesity reduction process,which is characteristic for hypothyroidism,because thyroid hormones are responsible for controlling metabolism. In addition,physical exercise increases blood HDL concentration during aerobic exercise and resistance training and improve the quality of life. Thus,the purpose of this study was to investigate the effect of aerobic and resistance training on the high-density lipoprotein cholesterol concentration in women with hypothyroidism Materials and methods. The sample consisted of 31 women with the hormonal rate stabilized by hormonal therapies for at least three months through the administration of a synthetic hormone levothyroxine sodium;the women were diagnosed with chronic hypothyroidism,but their thyroid-stimulating hormone (TSH) and T4 levels were stabilized (TSH level of 0.3–4.5 mU/L and free T4 level of 0.7–1.8 ng/dL). The sample was divided into the following three groups: aerobic training group (ATG,n = 10),resistance training group (RTG,n = 11),and control group (CG,n = 10);the women were selected at random from the Macapá city. The comparison of HDL concentrations between the sessions on week zero (T1) and on the 20th week (T2) between the three groups (CG,ATG,and RTG) was performed by one-way analysis of variance ANOVA,and the post-hoc Bonferroni correction test was applied when significant differences were observed. Results. For T1,the values of HDL concentrations in different groups were 46.2 ± 12.2 mg/dL (CG),50.1 ± 6.7 mg/dL (ATG),and 48.2 ± 8.0 mg/dL (RTG) and did not show any statistically significant difference (p = 0.64);for T2,the recorded HDL concentrations for different groups were 48.1 ± 8.9 mg/dL (CG),59.1 ± 10.5 mg/dL (ATG),and 61.4 ± 12.7 mg/dL (RTG);the values showed a statistically significant difference (p = 0.03) especially for RTG compared to CG with the mean difference of 12.26 mg/dL or 25.4% (p = 0.04). Conclusion. It can be concluded that physical exercise may have altered the HDL concentration profile in women with hypothyroidism compared to the control;the effect after 20 weeks of resistance training was especially significant.
关键词：Hypothyroidism;Physical exercise;Resistance training;Aerobic training
