摘要：Proposed is a procedure to test whether a genomic sequence contains coding DNA, called a coding potential region. The procedure tests the coding potential of conserved short genomic sequence, in which the assumptions on the probability models of gene structures
are relaxed. Thus, it is expected to provide additional candidate regions that contain coding
DNAs to the current genomic database. The procedure was applied to the set of highly conserved human-mouse sequences in the genome database at the University of California at Santa Cruz. For sequences containing
RefSeq coding exons, the procedure detected 91.3% regions having coding potential in this
set, which covers 83% of the human RefSeq coding exons, at a 2.6% false positive rate. The
procedure detected 12,688 novel short regions with coding potential at the false discovery
rate <0.05; 65.7% of the novel regions are between annotated genes.
