摘要：The Web-based software tool Genevestigator provides powerful tools for biologists to explore gene
expression across a wide variety of biological contexts. Its first releases, however, were limited by the scaling
ability of the system architecture, multiorganism data storage and analysis capability, and availability of
computationally intensive analysis methods. Genevestigator V3 is a novel meta-analysis system resulting
from new algorithmic and software development using a client/server architecture, large-scale manual
curation and quality control of microarray data for several organisms, and curation of pathway data for mouse
and Arabidopsis. In addition to improved querying features, Genevestigator V3 provides new tools to analyze
the expression of genes in many different contexts, to identify biomarker genes, to cluster genes into
expression modules, and to model expression responses in the context of metabolic and regulatory networks.
Being a reference expression database with user-friendly tools, Genevestigator V3 facilitates discovery
research and hypothesis validation.
