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  • 标题:Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review
  • 本地全文:下载
  • 作者:Takeshi Hirano ; Kazuyoshi Tamae
  • 期刊名称:Applied and Environmental Soil Science
  • 印刷版ISSN:1687-7667
  • 电子版ISSN:1687-7675
  • 出版年度:2010
  • 卷号:2010
  • DOI:10.1155/2010/726946
  • 出版社:Hindawi Publishing Corporation
  • 摘要:Earthworms can be used as a bio-indicator of metal contamination in soil, Earlier reports claimed the bioaccumulation of heavy metals in earthworm tissues, while the metal-induced mutagenicity reared in contaminated soils for long duration. But we examined the metal-induced mutagenicity in earthworms reared in metal containing culture beddings. In this experiment we observed the generation of 8-oxoguanine (8-oxo-Gua) in earthworms exposed to cadmium and nickel in soil. 8-oxo-Gua is a major premutagenic form of oxidative DNA damage that induces GC-to-TA point mutations, leading to carcinogenesis.
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