This paper deals with the combination of OFDM/OQAM with the Alamouti scheme. After a brief presentation of the OFDM/OQAM modulation scheme, we introduce the fact that the well-known Alamouti decoding scheme cannot be simply applied to this modulation. Indeed, the Alamouti coding scheme requires a complex orthogonality property; whereas OFDM/OQAM only provides real orthogonality. However, as we have recently shown, under some conditions, a transmission scheme combining CDMA and OFDM/OQAM can satisfy the complex orthogonality condition. Adding a CDMA component can thus be seen as a solution to apply the Alamouti scheme in combination with OFDM/OQAM. However, our analysis shows that the CDMA-OFDM/OQAM combination has to be built taking into account particular features of the transmission channel. Our simulation results illustrate the 2 × 1 Alamouti coding scheme for which CDMA-OFDM/OQAM and CP-OFDM are compared in two different scenarios: (i) CDMA is performed in the frequency domain, (ii) CDMA is performed in time domain.