To assess the performance of forthcoming 4th generation wireless local area networks, the algorithmic functionality is usually modelled using a high-level mathematical software package, for instance, Matlab. In order to validate the modelling assumptions against the real physical world, the high-level functional model needs to be translated into a prototype. A systematic system design methodology proves very valuable, since it avoids, or, at least reduces, numerous design iterations. In this paper, we propose a novel Matlab-to-hardware design flow, which allows to map the algorithmic functionality onto the target prototyping platform in a systematic and reproducible way. The proposed design flow is partly manual and partly tool assisted. It is shown that the proposed design flow allows to use the same testbench throughout the whole design flow and avoids time-consuming and error-prone intermediate translation steps.