摘要：Hydrocephalus, characterized by increased fluid in the cerebral ventricles, is traditionally evaluated by a visual
assessment of serial CT scans. The complex shape of the ventricular system makes accurate visual comparison
of CT scans difficult. The current research developed a quantitative method to measure the change in cerebral
ventricular volume over time. Key elements of the developed framework are: adaptive image registration based
on mutual information and wavelet multiresolution analysis; adaptive segmentation with novel feature extraction
based on the Dual-Tree Complex Wavelet Transform; volume calculation. The framework, when tested on
physical phantoms, had an error of 2.3%. When validated on clinical cases, results showed that cases deemed to be
normal/stable had a calculated volume change less than 5%. Those with progressive/treated hydrocephalus had a
calculated change greater than 20%. These findings indicate that the framework is reasonable and has potential for
development as a tool in the evaluation of hydrocephalus.
