首页    期刊浏览 2024年11月27日 星期三
登录注册

文章基本信息

  • 标题:Exact representations for tumour incidence for some density-dependent models
  • 本地全文:下载
  • 作者:P. R. Parthasarathy ; Klaus Dietz
  • 期刊名称:International Journal of Mathematics and Mathematical Sciences
  • 印刷版ISSN:0161-1712
  • 电子版ISSN:1687-0425
  • 出版年度:2005
  • 卷号:2005
  • 期号:16
  • 页码:2655-2667
  • DOI:10.1155/IJMMS.2005.2655
  • 出版社:Hindawi Publishing Corporation
  • 摘要:

    Carcinogenesis is a multistage random process involving generic changes and stochastic proliferation and differentiation of normal cells and genetically altered stem cells. In this paper, we present the probability of time to tumour onset for a carcinogenesis model wherein the cells grow according to a birth and death process with density-dependent birth and death rates. This is achieved by transforming the underlying system of difference equations which results in a continued fraction. This continued fraction approach helps us to find the complete solutions. The popular Moolgavkar-Venzon-Knudson (MVK) model assumes constant birth, death, and transition rates.

国家哲学社会科学文献中心版权所有