标题：Genetic Polymorphisms in Genes Related to Oxidative Stress (<i>GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS</i>) and Survival of Rectal Cancer Patients after Radiotherapy
摘要：Radiotherapy exerts part of its antineoplastic effect by generating oxidative stress, therefore genetic variation in
oxidative stress-related enzymes may influence survival of rectal
cancer patients. We hypothesized that genetic polymorphisms
associated with higher amounts of reactive oxygen species (ROS)
that exaggerate cytotoxic activity could improve survival after
radiotherapy. We followed 114 rectal cancer patients who received
radiotherapy for an average of 42.5 months. Associations between
genotypes (GSTP1, GSTM1,
GSTT1, CAT,
MnSOD, MPO and
eNOS) and overall survival were assessed using
Kaplan-Meier curves and Cox proportional hazards regression. As
hypothesized, patients carrying low ROS producing
eNOS Glu298Asp asparagine allele showed an
increased hazard of death compared to homozygous carriers of the
glutamine allele (hazard ratio (HR): 2.10, 95% confidence
interval (CI): 1.01–4.38). However, carriers of low ROS
producing MPO G463A A allele had a decreased
hazard of death compared to patients homozygous for the G allele
(HR: 0.44, 95% CI: 0.21–0.93) although patients
homozygous for the A allele had a slightly increased hazard (HR:
1.12, 95% CI: 0.25–5.08). This explorative study
provides first results and highlights the need for further, larger
studies to investigate association between genetic variation in
oxidative stress genes and survival of rectal cancer patients who
received radiotherapy.
