Spirituality has been found as the key indicator in enhancing the multiple levels of organizational success and accomplishment. The present study explores the relation ship between the spirituality and Job satisfaction of 121 branch managers, area managers and regional managers of various private and public sector banks of Pakistan. For the purpose of study an independent spirituality assessment scale (iSAS) developed by Rojas(2002) is used. Spirituality is quite significant in predicting the affective commitment of the employees. Limitations and future guidelines are also provided for future research.