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  • 标题:Geometrical study on diseaserelated ncRNAs based on Z-curve method
  • 本地全文:下载
  • 作者:Yan-Ling Yang ; Ji-Hua Wang
  • 期刊名称:Health
  • 印刷版ISSN:1949-4998
  • 电子版ISSN:1949-5005
  • 出版年度:2009
  • 卷号:1
  • 期号:1
  • 页码:24-30
  • DOI:10.4236/health.2009.11005
  • 出版社:Scientific Research Publishing
  • 摘要:The Z curve is a very useful method for visual-izing and analyzing DNA sequences. It is a three-dimensional space curve that constitutes a unique representation of a given DNA se-quence. It becomes more and more important to study non-coding regions in the recent years. Using Z curve method, 15 disease-related ncRNAs and some snoRNAs and miRNAs sequences are selected from the NONCODE database in this paper, which relate to Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are ob-tained. These features indicate that the ncRNAs sequences playing same roles in the celluar process have almost the same Z-curves. And the base content in these sequences is almost same too.
  • 关键词:Non-CodingRNA; Alzheimer Disease; snoRNA; miRNA; Z-Curve
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