摘要：Health socioeconomic gradients are well documented in developed countries, but
incompletely explained. A portion of these health inequalities may be explained by
environmental exposures. The objective of PAISARC is to explore the relations between
socioeconomic status, air pollution exposure and two selected health outcomes—asthma
exacerbations and myocardial infarction—at the level of a small area. The study design is
ecological, using data available from the national census, with the residential block
(French IRIS, 2000 people on average, National Institute of Statistics—INSEE)
as the statistical unit. The setting is the Greater Strasbourg metropolitan area
(450 000 inhabitants) in eastern France. We first constructed a socioeconomic
status index, using 1999 national census data and principal component analysis at
the resolution of these census blocks. Air pollution data were then modeled at
the same resolution on an hourly basis for the entire study period (2000–2005).
Health data were obtained from various sources (local emergency networks, the
local population-based coronary heart disease registry, health insurance funds)
according to the health outcome. We present here the initial results and discuss the
methodological approaches best suited for the forthcoming steps of our project.
