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  • 标题:OTC analgesics and drug interactions: clinical implications
  • 本地全文:下载
  • 作者:A Mark Fendrick ; Deborah E Pan ; Grace E Johnson
  • 期刊名称:Osteopathic Medicine and Primary Care
  • 印刷版ISSN:1750-4732
  • 电子版ISSN:1750-4732
  • 出版年度:2008
  • 卷号:2
  • 期号:1
  • 页码:2
  • DOI:10.1186/1750-4732-2-2
  • 语种:English
  • 出版社:BioMed Central
  • 摘要:The risk of drug interactions with concurrent use of multiple medications is a clinically relevant issue. Many patients are unaware that over-the-counter (OTC) analgesics can cause potentially serious adverse effects when used in combination with other common medications such as anticoagulants, corticosteroids, or antihypertensive agents. Of particular significance is the increased risk of upper abdominal gastrointestinal adverse events in patients who take traditional nonsteroidal anti-inflammatory drugs (NSAIDs). This risk is dose dependent and further increased in patients who take more than one NSAID or use NSAIDs in combination with certain other medications. Some NSAIDs may also mitigate the antiplatelet benefits of aspirin and may increase blood pressure in patients with hypertension. Clinicians should be aware of potential drug interactions with OTC analgesics when prescribing new medications. Additionally, patients should be properly counseled on the appropriate and safe use of OTC analgesics.
  • 关键词:Aspirin ; Ibuprofen ; Naproxen ; Antiplatelet Effect ; Nonselective NSAID
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