首页    期刊浏览 2024年11月24日 星期日
登录注册

文章基本信息

  • 标题:Nedaplatin: A Radiosensitizing Agent for Patients with Cervical Cancer
  • 本地全文:下载
  • 作者:Seiji Mabuchi ; Tadashi Kimura
  • 期刊名称:Boundary Value Problems
  • 印刷版ISSN:1687-2762
  • 电子版ISSN:1687-2770
  • 出版年度:2011
  • 卷号:2011
  • DOI:10.1155/2011/963159
  • 出版社:Hindawi Publishing Corporation
  • 摘要:

    Despite the recent advances in the management of cervical cancer using cisplatin-based concurrent chemoradiotherapy, substantial treatment failure still occurs, especially in advanced-stage patients and early-stage cervical cancer patients with high-risk prognostic factors. Therefore, efforts to further improve the survival and quality of life of these patients are necessary. Nedaplatin (cis-diammine-glycoplatinum), a derivative of cisplatin, was developed with the aim of producing a treatment with a similar effectiveness to cisplatin but decreased renal and gastrointestinal toxicities. Based on the promising results of preclinical studies, the clinical efficacy of nedaplatin as a radiosensitizing agent was evaluated in patients with cervical cancer. Retrospective analysis of nedaplatin-based concurrent chemoradiotherapy (CCRT) against cervical cancer suggested that nedaplatin-based CCRT can be considered as an alternative to cisplatin-based CCRT in both early-stage and advanced-stage cervical cancer patients. However, due to the lack of a randomized controlled study, nedaplatin-based CCRT has not been convincingly proven to be clinically effective in patients with cervical cancer. Further investigations in randomized controlled trials are therefore needed.

国家哲学社会科学文献中心版权所有