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  • 标题:Trends in Neonatal Lung Pathology
  • 作者:Grace Francis D'costa ; Milind Chincholikar ; Yoganand Patil
  • 期刊名称:Bombay Hospital Journal
  • 印刷版ISSN:0524-0182
  • 出版年度:2006
  • 卷号:48
  • 期号:04
  • 出版社:Bombay Hospital Institute of Medical Sciences
  • 摘要:Neonatal pulmonary pathology merits particular study, since respiratory disorders remain a major cause of neonatal mortality and respiratory pathology is the commonest autopsy finding in neonates. The present study was undertaken to examine the prevalence and type of pulmonary pathology encountered in neonatal autopsies. We compared two study periods 1989-91 and 1994 to note any changing trend. The Wigglesworth classification was utilized to classify deaths and the contribution of pulmonary pathology in each group was noted. 292 neonatal autopsies were analyzed. Pulmonary pathology contributed in a major way to neonatal mortality. It was the primary and secondary cause of death in 61.64% and 24.66% cases respectively and unfortunately the trend has not changed over a time interval. The most frequently encountered lesion was pulmonary haemorrhage 54.11% closely followed by pulmonary immaturity 52.25% both these leading causes did not show any changing trend. However it is heartening to note that, there was a sharp 50% drop in the incidence of hyaline membrane disease and bronchopneumonia, credit for which should go to the neonatologists. According to the Wigglesworth classification, the leading group as far as the cause of death was concerned was group III ‘Conditions associated with prematurity’, 50% but it was in group IV ‘Asphyxial lesions’-20-55% that pulmonary pathology contributed maximally to deaths 85% the main lesion being pulmonary haemorrhage.
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