标题：Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemia
出版社：American Society for Biochemistry and Molecular Biology
摘要：In this third installment of the series, we point out that theabsence of an explicit, detailed and plausible hypothesis linkinghypercholesterolemia to the events in the artery wall was probablyan important reason for continuing skepticism and for failureto treat elevated blood cholesterol levels.
The rapid advances in understanding of lipoprotein metabolismin the 1950s and 1960s and the application of modern cellularbiology in the 1970s provided the context for a modern consensuson pathogenetic mechanisms of atherogenesis.
