标题：Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy, part V: The discovery of the statins and the end of the controversy
出版社：American Society for Biochemistry and Molecular Biology
摘要：The first four reviews in this series (Steinberg, D. 2004. J.Lipid Res.45: 1583–1593; Steinberg, D. 2005. J. LipidRes.46: 179–190; Steinberg, D. 2005. J. Lipid Res.46:2037–2051; Steinberg, D. 2006. J. Lipid Res.47: 1–14)traced the gradual accumulation of evidence, evidence of severaldifferent kinds, supporting the lipid hypothesis. They trackedthe history from Anitschkow's 1913 classic work on the cholesterol-fedrabbit model to the breakthrough 1984 Coronary Primary PreventionTrial, the first large, randomized, double-blind primary interventiontrial showing that decreasing blood cholesterol (using cholestyramine)significantly reduces coronary heart disease events. At thatpoint, for the first time, decreasing blood cholesterol levelsbecame an official national public health goal. Still, onlya small fraction of patients at high risk were getting appropriatecholesterol-lowering treatment, and a number of important clinicalquestions remained unanswered. This final review in the seriestraces the early studies that led to the discovery of the statinsand briefly reviews the now familiar large-scale clinical trialsdemonstrating their safety and their remarkable effectivenessin reducing coronary heart disease morbidity and mortality.Supplementary key words inhibition of cholesterol biosynthesis • triparanol • compactin • lovastatin
