出版社：American Society for Biochemistry and Molecular Biology
摘要：This systematic review attempted to summarize the associationsbetween the Asn291Ser variant in the lipoprotein lipase (LPL)gene and dyslipidemia, the risk of type 2 diabetes mellitus(T2DM), and coronary heart disease (CHD). In addition, the relationshipsbetween the Asn291Ser variant and other metabolic diseases suchas obesity and high blood pressure were also investigated inthis systematic review. We systematically reviewed the literatureby means of a meta-analysis. Twenty-one articles, including19,246 white subjects, were selected for this meta-analysis.The summary standardized mean difference (SMD) of plasma triglyceride(TG) for carriers compared with noncarriers of the Asn291Servariant was 3.23 (P < 0.00001). The summary SMD of plasmaHDL-cholsterol (HDL-C) for carriers compared with noncarriersof the Asn291Ser variant was –3.42 (P < 0.0001). Thesummary SMD of the association of the Asn291Ser variant withplasma TG increased with increasing age and weight gain. Significantinteractions between the LPL Asn291Ser variant and fasting glucose,T2DM, and CHD were seen (P = 0.02, 0.04, and 0.01, respectively).No significant interactions were seen between the LPL Asn291Servariant and body mass index, waist–hip ratio, and bloodpressure (P > 0.05). This meta-analysis indicates that theAsn291Ser variant in the LPL gene is a risk factor for dyslipidemia,characterized by hypertriglyceridemia and low HDL-C levels.And the Asn291Ser variant in the LPL gene predisposes to moresevere dyslipidemia with increasing age and weight gain. Also,this meta-analysis shows that the LPL Asn291Ser variant is associatedwith CHD and T2DM.Supplementary key words dyslipidemia • type 2 diabetes mellitus • coronary heart disease • obesity • high blood pressure
Abbreviations: BMI, body mass index; CHD, coronary heart disease; HBP, high blood pressure; HDL-C, HDL-cholesterol; LPL, lipoprotein lipase; PL, pancreatic lipase; SMD, standardized mean difference; T2DM, type 2 diabetes mellitus; TG, triglyceride; WHR, waist–hip ratio
