文章基本信息

标题：Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol
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作者：Anuurad, Erdembileg ; Rubin, Jill ; Lu, Guijing 等
期刊名称：JLR Papers In Press
印刷版ISSN：0022-2275
电子版ISSN：1539-7262
出版年度：2006
卷号：47
期号：11
页码：2475-2481
DOI：10.1194/jlr.M600288-JLR200
出版社：American Society for Biochemistry and Molecular Biology
摘要：We studied the relationship of apolipoprotein E (apoE) isoformsand coronary artery disease (CAD) in 224 African Americans and326 Caucasians undergoing diagnostic coronary angiography. Thepresence of CAD was defined as >50% stenosis in at leastone artery. ApoE allele frequencies were 0.12, 0.62, and 0.26for ${epsilon}$ 2, ${epsilon}$ 3, and ${epsilon}$ 4, respectively, in African Americans and 0.08,0.78, and 0.14 for ${epsilon}$ 2, ${epsilon}$ 3, and ${epsilon}$ 4, respectively, in Caucasians.Among African Americans, CAD was present in 9 of 34 ${epsilon}$ 2 carriers(26%), significantly smaller (P < 0.05) in proportion comparedwith 39 of 82 ${epsilon}$ 3 carriers and 43 of 92 ${epsilon}$ 4 carriers (48% and 47%,respectively), suggesting a protective effect of the ${epsilon}$ 2 allele.No such difference was seen in Caucasians. In African Americansbut not Caucasians, LDL cholesterol was lower in ${epsilon}$ 2 carriersthan in ${epsilon}$ 3 and ${epsilon}$ 4 carriers (106 vs. 127 and 134 mg/dl, respectively;P < 0.005). After adjusting for lipid levels, the associationbetween apoE2 and CAD was no longer significant. Thus, the protectiveeffect of apoE2 seen in African Americans could be explainedby a favorable lipid profile in ${epsilon}$ 2 carriers, whereas in Caucasians,the absence of such a protective effect could be attributableto the lack of effect of apoE2 on the lipid profile. Supplementary key words coronary heart disease • polymorphism • cardiovascular risk factors • genetics