出版社：American Society for Biochemistry and Molecular Biology
摘要：Some studies have suggested that a modest increase of plantsterol levels is a risk factor for coronary artery disease (CAD).We studied the relationship between plant sterol levels andCAD risk in a prospective nested case-control study consistingof 373 cases and 758 controls. Sitosterol and campesterol concentrationsdid not differ between cases and controls [sitosterol, 0.21vs. 0.21 mg/dl (P = 0.1); campesterol, 0.31 vs. 0.32 mg/dl (P= 0.5)]. The sitosterol-to-cholesterol ratio was significantlylower in cases than in controls (1.19 vs. 1.29 µg/mg;P = 0.008), whereas the campesterol-to-cholesterol ratio didnot differ significantly (1.78 vs. 1.88 µg/mg; P = 0.1).Plant sterol concentrations correlated positively with cholesterollevels and inversely with body mass index and triglyceride andlathosterol concentrations. Among individuals in the highesttertile of the sitosterol concentration, the unadjusted oddsratio (OR) for future CAD was 0.75 [95% confidence interval(CI) = 0.56–1.01]. After adjustment for traditional riskfactors, the OR was 0.79 (95% CI = 0.56–1.13). For thecampesterol concentration, the unadjusted OR was 0.95 (95% CI= 0.71–1.29) and the adjusted OR was 0.97 (95% CI = 0.68–1.39).In this large prospective study, higher levels of plant sterols,at least in the physiological range, do not appear to be adverselyrelated to CAD in apparently healthy individuals.Supplementary key words sitosterol • campesterol • cholesterol • humans • European Prospective Investigation into Cancer and Nutrition
