出版社：American Society for Biochemistry and Molecular Biology
摘要：Docosahexaenoic acid (DHA; 22:6n-3) and n-6 docosapentaenoicacid (DPAn-6; 22:5n-6) are components of enriched animal feedand oil derived from Schizochytrium species microalgae. A onegeneration, artificial rearing model from day 2 after birthonward (AR) and a dam-reared control group (DAM) were used toexamine DPAn-6 feeding on the fatty acid composition of variousrat tissues at 15 weeks of age. Four AR diets were based onan n-3 fatty acid-deficient, 18:2n-6-based artificial milk with22:6n-3 and/or 22:5n-6 added: AR-LA, AR-DHA, AR-DPAn-6, andAR-DHA+DPAn-6. The 22:6n-3 levels for the DAM, AR-DHA, and AR-DHA+DPAn-6groups tended to be similar and higher than in the AR-LA andAR-DPAn-6 groups. The levels of 22:5n-6 tended to be higheronly in the absence of dietary 22:6n-3. Adipose levels of 22:5n-6was the only exception, as 22:5n-6 was significantly higherin AR-DHA+DPAn-6 than was observed in either the DAM or theAR-DHA group. There were no differences in 20:4n-6 levels withinthe tissues examined. In conclusion, 22:5n-6 replaces 22:6n-3in the absence of 22:6n-3 only and does not appear to competewith 22:6n-3 in the presence of dietary 22:6n-3, suggestingthat oils containing 22:5n-6 and 22:6n-3 may be a good dietarysource of 22:6n-3.Supplementary key words brain • heart • plasma • erythrocytes • liver • adipose • kidney • muscle • testes • gas chromatography
Abbreviations: AR, artificially reared; DAM, dam-reared; DHA, docosahexaenoic acid; DPAn-6, n-6 docosapentaenoic acid; HUFA, highly unsaturated fatty acid; LA, linoleic acid
