出版社：American Society for Biochemistry and Molecular Biology
摘要：A chronic inflammatory state is a risk factor for acceleratedatherogenesis. The aim of our study was to explore whether Crohn'sdisease (CD), characterized by recurrent inflammatory episodes,is also associated with accelerated atherogenesis. In 60 CDpatients and 122 matched controls, carotid intima media thickness(IMT), a validated marker for the burden and progression ofatherosclerosis, was assessed ultrasonographically. Additionalsubgroup analyses, including plasma levels of acute phase reactantsand HDL protein profiling, were performed in 11 consecutivepatients with CD in remission, 10 patients with active CD, and15 healthy controls. Carotid IMT in patients with CD was increasedcompared with healthy volunteers: 0.71 (0.17) versus 0.59 (0.14)mm (P < 0.0001), respectively. In the subgroup analysis,HDL levels in controls and patients in remission were identical[(1.45 (0.48) and 1.40 (0.46) mmol/l; P = 0.797], whereas HDLduring exacerbation was profoundly reduced: 1.02 (0.33) (P =0.022). HDL from patients with active CD and CD patients inremission was characterized by a reduced ability to attenuateoxidation compared with controls (P = 0.008 and P = 0.024 respectively).Patients with CD have increased IMT compared with matched controls,indicative of accelerated atherogenesis. The changes duringCD exacerbation in terms of HDL concentration and compositionimply a role for impaired HDL protection in these patients.Supplementary key words atherosclerosis • inflammation • endothelium
