标题：EXPRESSION OF CELLULAR ISOFORM OF PRION PROTEIN ON THE SURFACE OF PERIPHERAL BlOOD LYMPHOCYTES AMONG WOMEN EXPOSED TO LOW DOSES OF IONIZING RADIATION
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2007
卷号：14
期号：02
页码：225-225
出版社：Institute of Agricultural Medicine in Lublin
摘要：Ionizing radiation affects the expression of adhesive and co-stimulatory molecules
in lymphocytes. The physiological function of cellular isoform of prion protein
(PrPc) is little known. Evidences indicate a link between lymphocytes activation and PrPc
expression on their surface; however, no direct effect of radiation on PrPc level in these
cells was investigated. The objective of this study was to determinate the effect of low
doses of ionizing radiation on the expression of PrPc on the surface peripheral blood lymphocytes
in the women operating X-ray equipment. In 36 female workers and 30 persons
of the control group the PrPc expression on CD3 (T lymphocytes), CD4 (T helper), CD8
(T cytotoxic) and CD19 (B lymphocytes), as well as the percentage of lymphocytes with
PrPc on their surface, were tested. Subgroups with respect to age and length of employment
were selected. A signifi cant increase was observed in PrPc expression on CD3 and
CD4 with lowered PrPc level on CD8 and percentage of CD8 cells with PrPc in workers
compared to control. The PrPc level did not show signifi cant changes in subgroups in
relation to age (below and over 40 years old) both in the investigated and control groups,
whereas a lower percentage of PrPc expressing CD19 cells showed in employed women
below 40 years of age. A signifi cant decrease was found in PrPc expression on the surface
of CD3, CD4 and CD8 cells in the subgroup employed for over 10 years than in the subgroup
with less than 10 years of employment.
关键词：radiation exposure, cellular isoform of prion, lymphocytes.
