期刊名称：Neural Information Processing: Letters and Reviews
电子版ISSN：1738-2532
出版年度：2007
卷号：11
期号：4-6
页码：101-108
出版社：Neural Information Processing
摘要：Psychophysical experiments show that adaptation induced tilt aftereffect gets modulated under controlled
conditions of attention. The underlying neurophysiological mechanisms are unknown. Here using a population
model of primary visual cortex having detailed intrinsic and synaptic mechanisms we model orientation adaptation
and the effect of attention. We report that increased attention to orientation of adapting stimulus reduces
magnitude of the tilt aftereffect by modulating feedforward and intracortical synaptic efficacies. Without
mechanisms for synaptic modulation, increased alertness tends to increase the magnitude of the tilt aftereffect
via modulation of intrinsic membrane mechanisms. Our model is the first to relate multiple acetylcholine-induced
modulations of membrane and synaptic conductances to adaptation induced aftereffects. We also report that
attention to stimulus orientation opposes adaptation induced orientation plasticity, reducing the adaptation
induced repulsive shift of orientation preferences.
