The level of ¹⁴C carbaryl was determined in blood (leukocytes,
erythrocytes, all blood cells, plasma) and organs (brain, heart, lungs, liver,
spleen, skin at the site of exposure) of male Wistar rats after dermal
administration. The application liquid was ¹⁴C carbaryl solution in
96% ethyl alcohol. This preparation, possessing an activity of 670 kBq/ml,
containing 1.67 mg of carbaryl, was applied to the skin of the tail according to
Massmann's method in own modification. The amount of the preparation per 1 cm2
of the tail skin was 0.19 mg of carbaryl (74.4 kBq). The tails of experimental
rats were exposed to ¹⁴C carbaryl by soaking for 4 h daily: once,
twice or three times. Beta radiation from 14C was measured in homogenized organs
(brain, heart, lungs, liver, skin) and in blood by computer controlled Wallac
scintillation counter Model 1409, using Multi Calc software. The dermal
absorption of carbaryl at the site of exposure and in the surrounding area of
about 2 cm was observed already during 4 hour exposure. Carbaryl reached plasma
within 4 h of a single dermal exposure and penetrated into leukocytes,
erythrocytes, heart, liver, lung, kidney and brain. The largest amount of
¹⁴C carbaryl, about 2% of absorbed dose, was detected in liver