Background :There is a marked variability in the prevalence of Staphylococcal infections in different specialties. This study was done to find the prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) in different specialties of our hospital.

Methods : Various clinical specimens (Pus, Blood, Urine, CSF, Sputum, Ascitic and Pleural fluids) were processed and the pathogens were identified as per the standard bacteriological techniques

Results : A total of 4847 (8.89%) Staphylococcus aureus isolates were isolated from 54,486 clinical specimens. Amongst these, MRSA were 40.21%. Majority of the MRSA were from wound swab (68.19%). Amongst indoor patients, 91.49% MRSA were from wards and 8.51% were from Intensive Care Units. The antibiotic susceptibility pattern of MRSA showed 100% sensitivity to Vancomycin and Linezolid followed by Netilmicin (39.4%). All MRSA isolates were resistant to Penicillin.

Conclusion : The determination of prevalence and antibiotic sensitivity pattern of MRSA will help the treating clinicians for first line treatment in tertiary care hospitals