摘要：To assess
respiratory system response in long time low-level occupational exposure to
anesthetics (AE) and to identify appropriate prophylactic measures. Materials and Methods . Cross-section
study on 128 health care workers occupationally exposed to AE (halothane,
enflurane, isoflurane) vs matched
controls. GC exposure evaluation, clinical examination, immunochemistry,
respiratory function tests and oxidative stress markers (SOD, TBARS) were
performed. To assess the possible effect of AE on the immune function,
peripheral lymphocyte subpopulations, NK cells percentage and NK cytotoxic
activity were determined in a subgroup (n=33). Results . AE concentrations in
workplaces air were under but close to TLV. Irritative respiratory symptoms
prevailed. Discrete distal obstructions were found in 45.3% of workers vs 22.8% in controls ( c 2 =10.1, p<0.01,
OR=2.7, CI:1.4-5.2). SOD and TBARS were significantly higher in exposed
(p<0.01). Serum immunoglobulins changes suggested alteration of the humoral
immune response. The anaesthesiologist subgroup had a slightly reduced
percentage of specific cytotoxicity (12.34%) versus exposed (16.06%). Conclusions . It seems that under TLV
occupational exposure to anaesthetic gases could interfere with defence
mechanisms. Further research could sustain the reconsideration of exposure
standards - a suitable prophylactic approach.
关键词：respiratory health effects, occupational exposure, anesthetics, exposure standards
