摘要：The aim of our survey was to identify spondyloarthritis – associated to HLA -B
phenotypes in the population from north-eastern part of Romania. Genetic (HLA or
non-HLA genes) and infectious factors are involved in determining
spondyloarthritis susceptibility and severity. The most frequent association is
with HLA-B27 antigen, but the extent of
association of this antigen with spondyloarthritis depends on the ethnical and
geographical context of the population investigated. Patients and method : HLA-B antigens
were determined using the CDC-NIH (complement- dependent- cytotoxicity- National
Institute of Health) assay. We compared the frequency of HLA-B antigens
expression in the study group, consisting of 40 spondyloarthritis patients (35
with ankylosing spondilitis) and the control group, including 100 healthy
people. Results and conclusions :
HLA-B27, HLA-B7 and HLA-B35 antigens were expressed more frequently in patients
with spondyloarthritis compared to controls. The difference was statistically
significant for HLA-B27 and HLA-B7 antigens (p = 0.009 and p = 0.041). Although
HLA-B35 was present in 31.4% of the patients it did not involve a significant
risk for developing ankylosing spondilitis compared to controls (p = 0.445).
关键词：spondiloarthritis, HLA and non HLA genes, HLA-B27
antigen, susceptibility
