摘要：Hyperthermia is a type of cancer treatment in which cancer cells are exposed to
high temperatures (up to 44-45°C). Research has shown that high temperatures can
damage and kill cancer cells, by a localized and concentrated heating source. By
killing cancer cells and damaging proteins and structures within cells,
hyperthermia may shrink tumors, with minimal injury to normal tissues. In
addition to in vitro and in vivo studies, computer simulation can be used to
understand transport phenomena inside a tumor. In this study a spherical region
containing a magnetic particle embedded in a tissue is modeled using the bioheat
equation with the Penne's model for the thermal interaction between the tissue
and the perfused blood. Analytical techniques are used to solve the bioheat
equation with a point heat source of constant density power located as the
center of a spherical domain. The point heat source model the heat generated by
magnetic particles under the effect of an alternating magnetic field, used in
studies of local magnetic hypertermia. Parametric studies of the temperature
profiles are carried out to study the effect of different parameters like the
heat generation rate, perfusion rate and diameter of the point source on the
maximum temperature and on the temperature profile. Some discussion about
important parameters research issues in cancer hypertermia are also addressed.
