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  • 标题:Nonlinear PDE System as Model of Avascular Tumor Growth
  • 本地全文:下载
  • 作者:D. Fernández Slezak ; A. Soba ; C. Suárez
  • 期刊名称:Mecánica Computacional
  • 印刷版ISSN:2591-3522
  • 出版年度:2007
  • 卷号:XXVI
  • 期号:20
  • 页码:1788-1799
  • 出版社:CIMEC-INTEC-CONICET-UNL
  • 摘要:In this paper we present the solution of a partial differential equation system to model avascular
    tumors growth. A detailed finite-difference numeric algorithm for solving the whole system is presented.
    The system, that includes moving boundary condition and a two-point boundary equation, is solved
    using a predictor-corrector scheme. The model is sensitive to the used numerical method, so a secondorder
    accurate algorithm is necessary rather than a standard first-order accuracy one. A contracting
    mesh is also used in order to obtain the solution, as rate of change gets significantly high near tumor
    bound. Parameters are swiped to cover a wide range of feasible physiological values. Previous published
    works have taken into account the use of a single set of parameter values; therefore a single curve
    was calculated. In contrast, we present a range of feasible solutions for tumor growth, covering a more
    realistic scenario. A dynamical analysis and local behavior of the system is done. Chaotic situations arise
    for particular set of parameter values, showing interesting fixed points where biological experiments may
    be triggered
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