The purpose of this analysis is to examine telemedicine’s implications in the context of interpersonal communication. As telemedicine is a form of computer-mediated communication that exchanges and/or delivers healthcare information between people – particularly medical practitioners, patients, and general healthcare consumers – it is appropriate to investigate it in terms of its on-line, interpersonal communication conditions and corollaries. In order to do so, three interpersonal communication theories are considered specifically with respect to telemedicine: social penetration theory, uncertainty reduction theory, and social presence theory. By gaining an understanding of telemedicine as an interpersonal channel and a resource that seeks to facilitate interpersonal communication when geographical distance does not allow for face-to-face contact, new insights into telemedicine’s interpersonal implications can be seen, thereby enabling an exploration of how its “impersonal,” nature can reduced, if not eliminated.