摘要：Dietary polyphenols are considered beneficial because of their potential
protective role in the pathogenesis of chronic diseases associated to oxidative
stress. However, many of these effects may depend on the concentration of the
antioxidants used. The aim of the study was to evaluate the effect of quercetin,
chlorogenic acid and epigallocatechin on proliferation of human colon
adenocarcinoma cells Caco-2. Caco-2 cells were treated with different
concentrations (25, 50, 100, 200, and 400 μM in DMSO) of antioxidants and the
proliferation was assayed by MTT method. The results of the study indicated that
chlorogenic acid and quercetin enhanced Caco-2 cells proliferation in time- and
concentration-dependent manner. In contrary, epigallocatechin exhibit inhibitory
influence, particularly significant at concentration ≥ 200 μM.
